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J Endocrinol, 2024

Activation of alpha-2 receptors inhibits adenylate cyclase, and lowers intracellular cAMP, which reduces aqueous humour production by the ciliary body

Several clinical trials are examining all these different classes to increase or restore the activity of the mutated CFTR protein in patients (Clancy et al., Besides the general overlook of the main CFTR modulators reported in this section, many other therapeutic agents based on correctors and potentiators are undergoing various pre-clinical and clinical studies, and are extensively described by Rafeeq and Murad (2017)