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Corticosteroids Patients with UC and CD who do not achieve remission with 5-ASAs can be escalated to a more potent anti-inflammatory agent, such as corticosteroids

Neuron 20 , 103114 (1998)

Wan et al 2017: Impact of compound hypertonic saline solution on decompensated heart failure This is a single-center unblinded RCT in China involving 264 patients with systolic heart failure and refractory volume overload

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Marc LE, James HC, Avrum S