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There was also a considerable drop in the size of the kidneys from 5.5 to 2.8% as well as the reciprocal slope of the serum creatinine level from 3.81 to 2.61 mg per mL-1/year (240, 254)

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International analgesia and sedation weaning and withdrawal practices in critically ill adults: The adult iatrogenic withdrawal study in the ICU

The fairest one-line summary is that DSIP appears to have real biological activity but a weak and inconsistent clinical efficacy signal

[PubMed: 9406026] 44