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Description

IGF-1, structurally similar to insulin, serves as GH's principal anabolic mechanism, facilitating hypertrophy and potentially supporting cell division and development

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PMID 31119010

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To overcome these barriers, a strategy has been proposed that integrates multi-omics data with multicenter cohort studies consolidated into meta-cohorts, followed by stepwise validation using in silico , in vitro , ex vivo , and in vivo models

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Researchers studying the GH axis use this synergy to examine maximum pituitary GH secretory capacity, somatotroph reserve, and IGF-1 response dynamics in a way that single-compound protocols cannot replicate

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