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Vitamin C helps keep glutathione in its active, reduced state, which allows it to continue neutralizing free radicals over a longer period

Adjuncts such as GTN patches or shockwave can help stubborn cases

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Also, among all these compounds, quercetin-4'-O-beta-d-glucoside with a IC 50 value of 1.9 M is revealed stronger tyrosinase inhibition than their positive control, kojic acid 236

Third, pharmacokinetic, safety, and delivery constraints remain formidable, particularly for central nervous system indications

However, to fully understand the role of polyphenols in the medical management of these conditions, it is necessary to focus on the critical points and potential limitations derived from their use