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et al., 2017), The Continuous Stroke Surveillance Program in 31 Chinese provinces reported an annual increase of 8.3% in the incidence of first stroke in adults, from 189 cases per 100,000 people in 2002 to 379 cases per 100,000 people in 2013with the incidence of ischaemic stroke and hemorrhagic stroke at 335 per 100,000 population and 44 per 100,000 population, respectively, in 2013 (He et al., 2022)

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This is particularly relevant for medications with narrow therapeutic windows

doi: 10.1542/peds.113.5.e472 127 MulatinhoM

The use of PPIs can increase plasma gastrin levels by 35 times, dependent on treatment duration, necessitating suspension before testing, yet the 2024 guidelines do not address this [18]

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