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The tricarboxylic acid (TCA) cycle, glycolysis, fatty acid metabolism, and nucleotide synthesis are key metabolic pathways that maintain intracellular homeostasis and regulate DNA repair mechanisms

Potentially as a consequence of the heterogeneity of functionally redundant cell signaling networks and multiple genetic alterations 43 , glioblastoma remains largely refractory to current approaches of cancer therapy targeting specific signaling pathways 44

Photosynthesis as a hub of abiotic stress integration: ROS, Ca 2 , and hormonal cross-talk Photosynthesis is one of the most sensitive physiological processes to abiotic stresses, given its central role in plant growth, development, and productivity