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Funding Statement The study was funded by Wrwag Pharma, Germany (grant number: not applicable)

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Think of it as an amplifier

To summarize, an ideal candidate mechanism for counteracting tendency for runaway dynamics imposed by Hebbian-type learning rules on weight changes of excitatory synapses and activity in interneurons should fulfill the following requirements

Controlling systemic inflammation is non-negotiable for skin remodeling because chronic low-grade inflammation constantly degrades the extracellular matrix (ECM) faster than any peptide can rebuild it

Many patients need both, in sequence or simultaneously