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Du JP, Fan Y, Hao DJ, Huang YF, Zhang JN, Yuan LH

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TNF- and IL-1 trigger NADPH oxidases and mitochondrial dysfunction, enhance intracellular ROS production in fibroblasts, keratinocytes, and endothelial cells

Based on the evidence for direct beneficiary services noted above, our experience administering the Shared Savings Program, and the CMS Innovation Center's experience with AIM and infrastructure payments in the Next Generation ACO model, we have determined that allowing ACOs access to funding earlier than currently available, in the form of prepaid shared savings, would allow ACOs to more rapidly achieve the benefits of investing in staffing, healthcare infrastructure, and direct beneficiary services

Comment: One commenter supported the proposed modifications to the STEMI PCI measure under the newly titled IP PCI measure because the modifications intend to provide a more comprehensive, fair, and accurate assessment of costs associated with PCI procedures