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Ozawa M, et al

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Albumin levels are low in many disease states, resulting in lower total drug concentrations

In 1998, W McNeely reported the use of oral coumarin combined with ultraviolet A (UVA) exposure in patients with vitiligo [151]

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Sin embargo, tambin es capaz de participar en la conjugacin no enzimtica de algunos productos qumicos, como en el caso de la N-acetil-p-benzoquinona imina (NAPQI), el metabolito reactivo formado por la accin del sistema citocromo P450 sobre el paracetamol (o acetaminofeno, como se conoce en los Estados Unidos)