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A: Although usually very successful and safe, total hip and total knee replacements may be associated with a variety of complications, including infections and especially the formation of blood clots that can break off and then travel to the lungs (called pulmonary emboli or PE), just as happened to you

The downsides: Highest failure rate of any method

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The number of participants with a missing cotinine value also decreased over time from 202 in Period 1 to 28 in Period 2, and then to 1 in Period 3