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Int J Mol Sci 22(24):13322

104 , 6255 (2004) V.P

Effective inhibition of HIF-1 may significantly increase the efficacy of radiotherapy and chemotherapy by increasing radiosensitivity and chemosensitivity of tumor cells and also by upregulating anti-tumor immunity

Graphical abstract Similar content being viewed by others 1 Introduction Oxidative stress is caused by excessive production and accumulation of reactive oxygen species (ROS) in cells and tissues

HOCl targets most strongly the sulfur-containing amino acids cysteine and methionine with the second-order rate constant of k = 3 10 7 M 1 s 1 (Hawkins et al., 2003)