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This article by Cludia Barros Coelho, M.D., Ph.D., overviews some of the claims about dietary supplements and what the research shows to be true

In addition, seven candidate genes that may be involved in cold stress were selected based on the transcriptome analysis, and their promoters were analyzed to predict the factors that could regulate their expression

1979 Jan;60(1):14-17

Naturally, a hearty dose of vitamin C is at play, plus vitamin E (which helps stabilize the vitamin C), and niacinamide (which complements vitamin Cs brightening benefits)

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Endsley JJ, Furrer JL, Endsley MA, McIntosh MA, Maue AC, Waters WR, Lee DR, Estes DM: Characterization of bovine homologues of granulysin and NK-lysin