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In practice, the clinical trials for cagrilintide report tolerability outcomes and adverse event patterns alongside efficacy endpoints, because these factors influence dose escalation and continuation within a protocol

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Ongoing phase 3 trials for weight loss in non-T2D individuals are now utilizing a similar dosing protocol to that of semaglutide, starting at 0.25 mg/week with gradual titration every four weeks, up to a maximum of 2.4 mg/week [11]