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Becherer, J

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The acceleration of healing observed with T4 treatment translated to clinically meaningful improvements in wound closure rates and quality of life measures

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In-vitro and in-vivo studies have demonstrated that KISS1R activation in GnRH neurons triggers membrane depolarization and action potential firing, driving pulsatile GnRH release into the hypophyseal portal circulation and subsequent LH and FSH secretion from anterior pituitary gonadotrophs (Seminara et al., New England Journal of Medicine, 2003