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Among the 15 putative transcription factors, only MYC mRNA expression was significantly decreased by SLC13A3 knockdown in both HepG2 and SNU398 cells (Supplementary Fig

Given the difficulty of lowering ligands cost, developing smarter and more stable coupling to drugs could help to maximize their cost-effectiveness

Leukopenia and thrombocytopenia may occur with progressive splenomegaly

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Megaloblastic anemia Diminished activity of methionine synthase in vitamin B 12 deficiency inhibits the regeneration of tetrahydrofolate (THF) and traps folate in a form that is not usable by the body ( Figure 3 ), resulting in symptoms of folate deficiency even in the presence of adequate folate

Lieber C S, Relationships between nutrition, alcohol use, and liver disease,Alcohol Res Health