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Its accumulation reflects impaired glutathione regeneration, loss of regulatory control within the -glutamyl cycle, and metabolic conditions that favour diversion of intermediates away from productive glutathione synthesis

E., Savka, F

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Int J Gen Med 17:37193731

Consequently, this leads to a reduction in ROS production, MDA levels, and H 2 O 2 content, thereby maintain cellular membrane integrity

Neurodegenerative diseases are featured by a progressive loss of selective populations of vulnerable neurons and they and they can be classified as AD, Parkinsons disease, or motor neuron disease according to the clinical characteristics, including cognitive impairment, neuroinflammation, neuron loss, -amyloid accumulation, the collapse of proteostasis networks, and others (Hou et al., 2019)