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Sustained inflammation and oxidative stress can promote the activation and proliferation of HSCs, exacerbating the deposition of extracellular matrix and leading to the formation of fibrosis [224]

Importantly, significant reductions were observed across all three major FAST components: VCTE, CAP and AST

While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Johnson et al., 2019

Nishiyama et al, 2010), which is coupled to DNA replication through linking cohesin acetyltransferases ESCO1/2 with several replisome components including MCM, PCNA and CRL4 MMS22L (Ivanov et al, 2018

(5,6,10-12) Risk factors include: (7-10, 14-26) Obesity Recent Weight Gain Tight Clothing Pregnancy Tool Belts Trauma (Including seatbelt injuries) Prolonged Prone Positioning (i.e., Surgery) Diabetes (Nearly 6-fold increased risk) 2

Its important to note that cellulite is not harmful or indicative of any underlying health problems, although some may find it aesthetically undesirable