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The 2-year overall survival rate was also higher in patients with high MPV than in those with low MPV, at 64.7% vs 55.7%, respectively ( P = .001)

10.1007/s12011-012-9530-6 90

Apoptosis operates through two distinct pathways: the intrinsic pathway, which is dependent on internal signaling, primarily regulated by the BCL-2 family of proteins and involves mitochondria interactions, and the extrinsic pathway, which is dependent of external signaling and independent of BCL-2 and mitochondrial involvement (Jan and Chaudhry, 2019)

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doi:10.1155/2017/3050895 Olas B

Annuzzi G, Rivellese AA, Bozzetto L, et al