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However, the beneficial effect was not replicated in the larger and more stringently performed phase III EMBODY trial (25)

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Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity

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