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FDA review material for tesamorelin noted that loss of VAT benefit after discontinuation was observed by the earliest measured time point after stopping in extension data what researchers commonly describe as tesamorelin VAT rebound after discontinuation

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Summary: IGF-1 is a hormone typically made in the liver in response to growth hormone secretion

[8] Once activated, these G-proteins may stimulate the production of second messengers like cAMP or IP3, which appear to act as secondary signaling molecules, potentially further propagating the signal within the cell

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