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10.1111/bjd.19244 2 AlmeidaL.LochnerM.BerodL.SparwasserT

Luciferin, em = 520 20 nm, 200 ms

Both PGE2 and PGI2 are pro-inflammatory prostanoids that increase vascular permeability, promote leukocyte infiltration and increase edema formation 4

1h) HAP1-wt or HAP1ADH5 cells were seeded with 100000, 50000, 25000 or 12500 cells per well into 12-well plates

CYP-mediated metabolism constitutes schisandrins primary clearance route (64), with CYP2B, CYP2C, CYP2D, and CYP3A crucially facilitating biotransformation (65)