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Strzelczyk A, Griebel C, Lux W et al (2017) The burden of severely drug-refractory epilepsy: a comparative longitudinal evaluation of mortality, morbidity, resource use, and cost using german health insurance data

Whereas arginine supplementation increased the disposal of arginine and subsequent conversion to ornithine before entering the peripheral circulation, citrulline supplementation increased the disposal of plasma arginine into ornithine

This, however, is a non-a-priori correlation, not corrected for multiple comparisons, and therefore should be viewed with caution

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Olpin SE, Clark S, Andresen BS, Bischoff C, Olsen RKJ, Gregersen N, Chakrapani A, Downing M, Manning NJ, Sharrard M, Bonham RJ, Muntoni F, Turnbull DN, Pourfarzam M (2005) Biochemical, clinical and molecular findings in LCHAD and general mitochondrial trifunctional protein deficiency

Monitoring may be required in some patients