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This finding was in good accordance with the literature, where the hydroquinone is routinely shown to auto-oxidate under these conditions 30,31

These inflammatory mediators affect hypothalamic-pituitary-ovarian axis signals and can modify cycle timing, LH surge precision, and follicular development

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Cytokine and chemokine assays Protein was extracted using a 2-cm piece of distal colon and homogenized in 300 l of Meso Scale Discovery lysis buffer with protease and phosphatase inhibitors as described in the assay protocol