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The models were refined using a combination of manual adjustments in COOT (version 0.9.8.7) 46 , automated real-space refinement in PHENIX (version 1.21) 47 and semi-automated refinement using ISOLDE (version 1.7.1) in ChimeraX (version 1.7) 48,49,50

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She shared how, at the time of her diagnosis, there were virtually no resources except for end-of-life care

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