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The process of age-standardization of rates is a classic epidemiological method that removes the confounding effect of differences in age structure between the populations being compared, and the formula is as follows: The ASR (per 100,000 population) is equal to the sum of the product of the specific age ratio (a i , where i denotes the i th age class) and the number of persons (or weight) (w i ) in the same age subgroup i of the chosen reference standard population, then dividing the sum of standard population weights

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