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Methods: From patient data (n=9919) enrolled in the cohort of PBC, we extracted patients in which ALP level at presentation, presence or absence of treatment during the course of the disease, and long-term prognosis were all recorded

Gamma-glutamyl transferases: a structural, mechanistic and physiological perspective

Mori K, Togashi H, Kojima T, Matsumoto M, Ohashi S, Ueno K, et al

Ezzedine K, et al

This rapid proliferation is primarily driven by the pro-inflammatory cytokines secreted by Th1 and Th17 cells, particularly IL-17 and IL-22, which promote keratinocyte proliferation and inhibit their normal differentiation (Ortiz-Lopez et al

The formation of ROS and the mechanism of apoptotic cell death were studied using the DCFDA and Annexin-V/FITC-PI assays, respectively