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Description

Hydroxysafflor yellow a alleviates acute myocardial ischemia/reperfusion injury in mice by inhibiting ferroptosis via the activation of the HIF-1alpha/SLC7A11/GPX4 signaling pathway

Oncotarget 8 , 2662526636 (2017)

Some minor adverse effects have been noted in humans

Due to their high rate constant and high abundance, Prx are thought to be responsible for scavenging nanomolar concentrations of H 2 O 2 associated with redox signaling, while Gpx are likely important at higher intracellular concentrations, buffering high ROS levels to avoid cell damage and stress signaling response (Sena and Chandel, 2012)