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Excess ROS can damage all major cellular constituents (DNA, proteins, and lipids) and even lead to cell death, apoptosis, hypertrophy, fibrosis, and contractile dysfunction in the myocardium [8, 11]

Improved regulation of CBF in response to both transient hyper- and hypotension subsequently protects cerebral microvasculature from hyperperfusive injury and damage as well as ensuring cerebral perfusion is able to match metabolic demand during periods of reduced driving pressures (i.e., orthostatic stress) (Claassen et al., 2021)

Hong SJ, Kim SI, Kwon SM, et al

And the reason being is that we don't have to adapt anymore for the change of seasons because our our environment is totally controlled

For instance, a patient suffering from chronic inflammation might be advised to follow an anti-inflammatory diet, take specific supplements to reduce inflammation, and engage in stress-reducing activities like yoga or meditation

Cao, P., et al., Therapeutic approaches to modulating glutathione levels as a pharmacological strategy in Alzheimers disease