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Other small molecules that have anticoagulant properties include -halomethyl carbonyls (irreversible, high-affinity active site inhibitors of FXIIIa preventing fibrin cross-linking), imidazolium derivatives (irreversible active site inhibitors of FXIIIa), and inhibitors that contain imidazo-thiadiazole (formation of inhibitor-FXIIIa adduct resulting in covalent inhibition of enzyme activity) [44]

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