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Cobalt or B12 deficiency impacts energy and protein metabolism, causing a starvation of sorts

NNMT Inhibitors are Selective and do not Impact Related Methyltransferases or Enzymes in the NAD+ Salvage Pathway

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This distinguishes it from GLP-1 receptor agonists like semaglutide that work through gut hormones and appetite suppression

These adaptations may explain why metabolic benefits can continue to improve over weeks to months of consistent use, rather than plateauing immediately

According to the NIH Office of Dietary Supplements, B12 is essential for red blood cell formation, neurological function, and DNA synthesis