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Subsequently, various chemokines and growth factors refined by activated endothelial cells and macrophages act on adjacent smooth muscle cells (or their precursor 12), inducing their proliferation and synthesis of extracellular matrix components in the intimal compartment, resulting in fibromuscular plaques [104]

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The adult segment's steadiness offers a reliable revenue base, while the youth segment's growth presents expansion avenues, albeit with a need for astute regulatory navigation and active stakeholder dialogue

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In the other groups, at the highest dose, toxic signs such as weakness, laboured respiration, and tremor were observed with a mortality rate of 19 - 48%