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Consequently, the IKK complex phosphorylates IB proteins, leading to its ubiquitination and proteasomal degradation, releasing NF-B dimers, namely p50/p65 and p50/Rel dimers (Li and Verma 2002

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Quantitative PCR analysis showed significantly increased levels of acyl-CoA synthetase short chain family member 2 ( Acss2 ) 32 , carbohydrate response element binding protein a ( Chrebpa ) 33 , acetyl-CoA carboxylase alpha ( Acaca ) 34 , sterol regulatory element-binding protein 1C ( Srebp1c ) 35 , and stearoyl-CoA desaturase-1 ( Scd1 ) 36 in HFD and HFHC-fed G3BP1 LKO mice compared to WT mice (Fig

In: Bhattacharye SK (ed) Molecular Aspects of Asian Medicines