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Footnotes 1 Studies that have used similar nicotine and placebo preparations have reported that, compared with a placebo condition, one 4-mg nicotine gum piece increases plasma nicotine levels by approximately 810 ng/mL within 30 minutes, and has a half life of approximately 120 minutes [2326]

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Worldwide, one-in-ten adult deaths (about 5 million deaths annually) are attributable to tobacco, according to the Organisation for Economic Cooperation and Development (OECD)

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Funding The research reported in this publication was supported by the Fogarty International Center (FIC) of the National Institutes of Health (NIH) under Award Number D43TW011625

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