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In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat

Correlative data from an ongoing Phase 1, multicenter study of senti-202, a first-in-class, CD33 and/or FLT3 & not endomucin (EMCN), selective off-the-shelf CAR NK cell therapy for Acute Myeloid Leukemia (AML) is consistent with its clinical activity and unique logic gated mechanism of action

(Source 1) Iron deficiency exists on a spectrum from depleted iron stores to iron-deficiency anemia

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Most of these previous trials were conducted in a select group of patients with the following characteristics: 1) predominantly receiving complete nutrition support via PN, 2) common exclusion of renal and liver failure based on glutamine product prescribing restrictions, 3) GLN supplementation of PN is often initiated later in the ICU stay (not at ICU admission during the shock phase), as PN is typically started later in the stay when enteral nutrition (EN) is not possible or meeting nutritional needs, 4) enrollment of oncology patients who may be at a greater risk for tumor-mediated GLN depletion, 5) use of GLN dose between 0.3 g/kg/day to a maximum of 0.5 g.kg/day given only via the intravenous route

References Trichuris trichiura (Linnaeus 1758) of man and Trichuris suis (Schrank 1788) of the pig*