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J Neurosci 24(36):777988, PubMed PMID: 15356189 Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J (2010) NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

The carboxylic group of the drug reacts with ATP and the AMP ester of the drug is formed

The paper highlights GHK-Cus ability to modulate gene expression, affecting a large number of genes related to tissue repair, anti-cancer activity, anti-inflammatory actions, and DNA repair