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NNMT inhibition reduces one methylation pathway, but it doesn't directly deplete systemic methyl donorsit redirects nicotinamide away from methylation toward NAD+ salvage

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that responsibility lies with the FDA

This combination is most often discussed by people dealing with tendon issues, recurring soft-tissue injuries, training-related inflammation, or recovery limitations

IgG4 was still a minor contributor to all anti-S antibodies in that study, suggesting confounding effects in this cohort