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At the treatment level, strategies such as hypoxic axis inhibition, lipid suppression/induced ferroptosis, and glutamine and one-carbon metabolism provide a solid mechanistic basis and a transformational path for rational use with ICI/TKI/antivascular treatments

In this stage, amyloid plaques infiltrate the midbrain and medulla and NFTs are found in neocortical association cortices (Koychev et al., 2020)

A key focus is placed on the dysregulation of the kynurenine pathway of tryptophan metabolism, which mechanistically links immune activation to neurotransmitter imbalances

These mediators, including microbial structural components and metabolic byproducts, act as molecular messengers that transduce local microbial activity into systemic physiological or pathological responses (Fig

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