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LC-MS/MS instrumentation and conditions LC-MS/MS analysis was performed using a Waters UPLC instrument with an Acquity TM binary solvent manager, Acquity TM 4-position heated column manager and 2777 Ultra High Pressure Autosampler coupled to a Xevo-TQ MS triple quadrupole mass spectrometer (Waters Ltd, Herts, UK) with an electrospray ionisation (ESI) source

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