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Of note, Insr expression was found upregulated in mouse lungs with compromised IGF1R signaling [21,22,23, 37], and IGF1 expression by the TME was reported to have a supportive role in tumor initiation and progression [16, 24]

Cells were continuously maintained in a humidified incubator at 37 C, 5% CO 2

At the high end (20 units): 2 mg per injection

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doi: 10.1371/journal.pone.0039836 29 LuoBLiBWangWLiuXXiaYZhangCet al

It is noteworthy that NQO1 has been implicated in the bioreduction of various nitroheterocyclic compounds, which is essential for inducing their anticancer activities