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A large systematic review of these approved medicationstogether with a variety of commonly used off-label medications [including baclofen (a gamma-aminobutyric acid-B receptor agonist), gabapentin, and topiramate]has been recently performed, including data from 118 clinical trials that collectively included 20,976 patients

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Mol Cell (2019) 73:35463.e3

Free radicals are believed to be among the primary causes of sagging and dulling of their epidermis

Barbieri RL, Ehrmann DA