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Tobacco addiction is a chronic substance use disorder characterized by the compulsive and uncontrollable use of tobacco products, primarily driven by the psychoactive effects of nicotine, resulting in both physical and psychological dependence

Spada MM, Caselli G, Nikevi AV, Wells A

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Maintaining good oral hygiene, staying hydrated, and using throat lozenges can help alleviate some of the irritation caused by smoking

tri-phasic) and dose of OC, (3) including refined measurement of the relationship between endogenous hormones and smoking-related outcomes by including absolute and change of endogenous hormone values given smoking behavior has been associated with endogenous hormone changes in naturally cycling women, 15,112 (4) comparing OC use by long-time users versus first-time users as recommended by Oinonen and Mazmanian 51 to avoid a survivor effect (ie, those who have been using OCs for a lengthy period of time may be effected by OCs differently than those who are using OCs for the first time), and (5) including examination of potential effect modifiers such as race and personal/family history of depression