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In endometrial settings, Xu et al

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Antioxidants & redox signaling 13 , 769781 (2010)

31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%

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9 In contrast, the placebo group experienced a decrease in immune cell numbers