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Hence the decrease in GSSG is in keeping with GPX1 being one of the major enzymes that uses GSH as an electron donor to generate GSSG

What, then, explains the phosphorylation of tyrosine at (relatively) low peroxynitrite concentrations

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All chemicals were used as received without further purifications

The vehicle utilized in these experiments was 2% serum obtained from sibling mice diluted with nanopure water under sterile conditions

A number of studies have revealed that exosomes can regulate the function of target cells by secreting their contents into the TME, using crosstalk, and/or influencing major tumor-related pathways, including EMT, CSCs, angiogenesis, and metastasis involving several cell types (Wu et al., 2017)