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Notably, NNMT inhibition did not impact food intake in the DIO mice nor produce any overt signs of toxicity or adverse behavioral effects at the pharmacologically effective dose

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Common signs include: Ongoing fatigue or weakness Pale skin Numbness or tingling in the hands and feet Brain fog, forgetfulness, or trouble concentrating Low mood, anxiety, or irritability Poor appetite or digestive upset When B12 is low, your metabolism slows, you have less energy for activity, and appetite signals can get thrown off, all of which make weight loss harder