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The main efflux pumps are the ATP-binding cassette (ABC) transporters

396 Moreover, demethylation treatment can disrupt protein methylation, leading to the accumulation of SAH while depleting cellular SAM, resulting in the inhibition of autophagy and apoptosis induced by endoplasmic reticulum stress in pancreatic cancer cells

13.1%, p =0.03) than NUCs alone, but not in mild cases ( p =0.50)

Immune dysregulation due to evasion strategies or host factors facilitates disease progression and drug resistance

The differences that existed between the evaluated study groups were assessed by performing an analysis of variance (One-way ANOVA) and the post hoc test (Tukey test) to conduct pair-wise comparisons