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The clinic is also the clinical arm of the Mass General/MIT Udall Center for Excellence in Parkinson's Research Massachusetts General Hospital Deep Brain Stimulation Program provides deep brain stimulation as a treatment for a variety of neurological disorders including Parkinsons disease and different types of dystonia

Mol Metab 2022;65:101590.ArticlePubMedPMC 80

Accordingly, pharmacological inhibition of SLC7A11 or cysteine deprivation blocks GSH synthesis, leads to GSH depletion, and induces ferroptosis by disabling the antioxidant defense system 85,137

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Specifically, SHMT1 binds to the 5 untranslated region (UTR) of its own mRNA to suppress translation, while also interacting with the 5 UTR of SHMT2 mRNA to reduce transcript stability and protein expression (Fig

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