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Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: A randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)

2.8 Protein-protein interaction network construction and module analysis Utilizing the outcomes of machine learning feature selection, the chosen feature genes were employed to establish a protein-protein interaction (PPI) network using the string database (33), aiming to elucidate the intricate regulatory associations among the corresponding proteins of the feature genes

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Optimization process: After discretization, the optimal control problem is formulated to minimize M2 macrophage activity and, thus, reduce fibrosis 29,30