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Because of the high heterogeneity of tumors, according to Darwinian evolutionary principles, drug-resistant mutants are selected, or subpopulations of primary resistant tumor stem cells in the dormant phase can cause tumors to regrow or spread

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Inspired by this discovery and the following studies, Hui Wei and Erkang Wang published a review in 2013 that began using nanozymes to specifically describe nanomaterials with enzyme-like characteristics 29

References Hasin DS, Sarvet AL, Meyers JL, Saha TD, Ruan WJ, Stohl M, et al

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