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It is also generally the first amino acid to be depleted

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Neurologic symptoms of pellagra include headache, fatigue, apathy, depression, ataxia, poor concentration, delusions, and hallucinations, which can lead to confusion, memory loss, psychosis, and eventual death (27)

Oxidative status in granulosa cells of infertile women undergoing IVF

Mito-TEMPO (Sigma-Aldrich, Milan, Italy) was solubilized in DMSO and added to the cells simultaneously with the medium change 24 h before the viability assay